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  • Title: A quantity of stereotyped behavior of ddY mice induced by low-dose methamphetamine.
    Author: Masuda Y, Matsuda Y, Kondoh M, Shimizu T, Hishikawa Y.
    Journal: Exp Anim; 1996 Jul; 45(3):279-81. PubMed ID: 8840148.
    Abstract:
    It is reported that high-dose methamphetamine (8 mg/kg) induces stereotyped behavior in ddY mice in an open field, but it is still not certain that low-dose methamphetamine (less than 2 mg/kg) can induce the stereotyped behavior in ddY mice in a narrow space. In order to investigate the problem, we evaluated the quantity of stereotyped behavior of ddY mice by using a mouse wheel-running apparatus. In this method, we have come to recognize an increase in the stereotyped behavior depending on the dose of methamphetamine and the reverse-tolerance phenomenon as a decrease in the wheel-revolution counts. The present findings indicate that low-dose methamphetamine can promote stereotyped behavior in ddY mice under conditions in which the ambulation is restricted to a narrow wheel space.
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