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  • Title: Prolonged ciprofloxacin administration does not accelerate neutrophil recovery after autologous bone marrow transplantation.
    Author: Hsu J, Prince HM, Imrie KR.
    Journal: Pharmacotherapy; 1996; 16(4):652-5. PubMed ID: 8840372.
    Abstract:
    STUDY OBJECTIVE: To determine whether prolonged ciprofloxacin administration following autologous bone marrow transplantation (ABMT) accelerates neutrophil recovery. DESIGN: Retrospective analysis of 40 consecutive patients undergoing ABMT. SETTING: Tertiary care bone marrow transplant program. PATIENTS: Two sequential arms of 20 consecutive patients with Hodgkin's disease or non-Hodgkin's lymphoma undergoing ABMT. INTERVENTIONS: The first arm received ciprofloxacin from the day of transplantation until initiation of broad-spectrum antibiotic therapy (median 5 days) while the second arm continued ciprofloxacin until recovery of the neutrophil count (median 15 days). MEASUREMENTS AND MAIN RESULTS: Neutrophil recovery was similar in the two groups (16 vs 14 days; p = 0.41). There were no differences in platelet recovery, bacteremia, or treatment-related mortality. CONCLUSION: Prolonged ciprofloxacin administration does not significantly accelerate neutrophil recovery following ABMT.
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