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  • Title: Efficient guanine alkylation through cooperative heterodimeric formation of duocarmycin A and distamycin A.
    Author: Isomura M, Sugiyama H, Saito I.
    Journal: Nucleic Acids Symp Ser; 1995; (34):47-8. PubMed ID: 8841545.
    Abstract:
    Antitumor antibiotic Duocarmycin A alkylates adenines at the 3 end of sequences of three or more consecutive A or T base pairs through binding to the minor groove of DNA. In the presence of distamycin A, duocarmycin A was found to alkylate guanine residue in G-C rich sequences, which are not alkylated by duocarmycin A alone. Efficient guanine alkylation through cooperatively binding of a heterodimer in the minor groove of DNA will be discussed.
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