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  • Title: Comparative CD and thermodynamic studies between sheared A:G and Watson-Crick A:U(T) base pairs in RNA and DNA.
    Author: Katahira M, Saeki J, Kanagawa M, Nagaoka M, Uesugi S.
    Journal: Nucleic Acids Symp Ser; 1995; (34):59-60. PubMed ID: 8841551.
    Abstract:
    Thermodynamic parameters for duplex formation were determined from CD melting curves for r(GGACGAGUCC)2 and d(GGACGAGTCC)2, both of which have been demonstrated to form two consecutive 'sheared' A:G base pairs at the center by our previous studies. The parameters were determined also for r(GGACUAGUCC)2 and d(GGACTAGTCC)2, where the A:G mismatches are replaced by Watson-Crick A:U(T) base pairs. Thermodynamic properties for duplex formation are compared between the sheared and the Watson-Crick base pairs, and between RNA and DNA. Difference in the thermodynamic stability is analyzed and discussed in terms of enthalpy and entropy changes.
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