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  • Title: Ischemic colitis during interferon-alpha treatment for chronic active hepatitis C.
    Author: Tada H, Saitoh S, Nakagawa Y, Hirana H, Morimoto M, Shima T, Shimamoto K, Okanoue T, Kashima K.
    Journal: J Gastroenterol; 1996 Aug; 31(4):582-4. PubMed ID: 8844482.
    Abstract:
    Between 1991 and 1994, at Hoshigaoka Koseinenkin Hospital, we treated 280 patients with chronic hepatitis C with interferon (IFN), and ischemic colitis occurred in two patients (0.7%) during the treatment. Melena appeared in case 1 in the 2nd month after the initiation of IFN-alpha treatment, and in case 2 in the 6th month. In both patients, longitudinal ulcerations in the descending colon were revealed by urgent colonoscopy, and these resolved within 2 weeks after discontinuation of the IFN treatment. It appears that ischemic colitis was associated with the IFN treatment, suggesting that attention should be paid to this possible complication.
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