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  • Title: Nitrous oxide depresses somatocardiac sympathetic A- and C-reflexes in anesthetized rats.
    Author: Adachi T, Miyazaki Y, Kurata J, Utsumi J, Shinomura T, Nakao S, Murakawa M, Shichino T, Mori K.
    Journal: Neurosci Lett; 1996 Jul 26; 213(1):57-60. PubMed ID: 8844712.
    Abstract:
    Effect of nitrous oxide (N2O) on the somatosympathetic A- and C-reflexes was investigated using artificially ventilated rats anesthetized with alpha-chloralose and urethane. Somatocardiac sympathetic A- and C-reflexes were elicited in the inferior cardiac nerve by electrical stimulation of A and C afferent fibers of the tibial nerve, respectively. Both reflexes were depressed by inhalation of N2O for 20 min. The depression was greater in the C-reflex than in the A-reflex. The depressive effects of N2O on both reflexes were unchanged after pretreatment with intravenous naloxone (0.2 or 2.0 mg/kg) or by prolongation of the inhalation of N2O for 2 h. These results suggest that the opioid receptor is not involved and that acute tolerance is not developed in the depressive action of N2O on the somatosympathetic A- and C-reflexes.
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