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  • Title: Cytotoxic activity and transformation of BALB/c 3T3 cells in vitro by the insecticide acephate.
    Author: Perocco P, Del Ciello C, Colacci A, Pozzetti L, Paolini M, Cantelli-Forti G, Grilli S.
    Journal: Cancer Lett; 1996 Sep 10; 106(2):147-53. PubMed ID: 8844966.
    Abstract:
    Cytotoxic and cell transforming activity of the organophosphate insecticide acephate have been studied in an in vitro experimental model which foresees the exposure of BALB/c 3T3 cells to the chemical. The assay was performed in the presence or absence of metabolic activation system derived from phenobarbital and beta-naphthoflavone induced rats (S9-mix). Cytotoxicity of acephate was unaffected by the presence of the metabolizing fraction. Cell-transforming potential, evidenced through the induction of transformation foci, was observed at all tested doses (i.e. 100, 200 and 400 micrograms/ml) with or without exogenous bioactivation. This activity was related with cell proliferation since it was particularly evident in a level-II cell-transformation assay when the cells were allowed to perform active proliferative activity. These findings, obtained in a medium-term (6-8 weeks) test, may contribute to a better understanding of the action of acephate in the multistep carcinogenesis, proving more information on the oncogenic risk to humans.
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