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  • Title: Multicentre clinical trial with herpes simplex virus vaccine in recurrent herpes infection.
    Author: Mastrolorenzo A, Tiradritti L, Salimbeni L, Zuccati G.
    Journal: Int J STD AIDS; 1995; 6(6):431-5. PubMed ID: 8845402.
    Abstract:
    The aim of this work was to confirm our preliminary clinical and immunological evaluation of the protective effects of a herpes simplex virus (HSV) vaccine derived from killed virus in the treatment of relapsing facial or genital herpes simplex infection. A total of 142 patients were treated with the HSV vaccine and a control group of 50 were treated with intermittent oral acyclovir (ACV). The vaccine reduced annual active disease days in vaccinees to 11.59 (+/- 15.3) after treatment (65.11 +/- 31.64 before treatment) compared to 30.4 +/- 17.49 days after treatment of the control group patients (71.86 +/- 32.5 before treatment).
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