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  • Title: Rat adrenomedullin induces a selective arterial vasodilation via CGRP1 receptors in the double-perfused mesenteric bed of the rat.
    Author: Berthiaume N, Claing A, Lippton H, Cadieux A, D'Orléans-Juste P.
    Journal: Can J Physiol Pharmacol; 1995 Jul; 73(7):1080-3. PubMed ID: 8846405.
    Abstract:
    The present work was undertaken to study the effect of rat adrenomedullin (rADM (1-50) and its C-terminal fragment (11-50)) in the endothelium-intact arterial and venous vasculatures of the rat perfused mesenteric bed. rADM (1-50) and the fragment rADM (11-50)(1-1000 pmol) induced a dose-dependent and endothelium-independent vasodilation on the arterial mesenteric vasculature. However, both peptides were inactive on the venous side of this vascular bed. The CGRP1 receptor antagonist, hCGRP8-37 (1 microM), markedly reduced the vasodilation caused by rADM (1-50) in the arterial mesenteric vasculature. Thus, our results show that rADM (1-50) in the arterial mesenteric vasculature. Thus, our results show that rADM (1-50) and its C-terminal fragment rADM(11-50) share properties similar to those of hCGRP. The blocking effect of hCGRP8-37 supports a role for CGRP1 receptor activation by adrenomedullin in this vascular preparation.
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