These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Detection of measles virus nucleoprotein mRNA in autopsied brain tissues.
    Author: Katayama Y, Hotta H, Nishimura A, Tatsuno Y, Homma M.
    Journal: J Gen Virol; 1995 Dec; 76 ( Pt 12)():3201-4. PubMed ID: 8847530.
    Abstract:
    By means of RT-PCR, a portion of measles virus (MV) mRNA encoding nucleoprotein (NP) could be detected in 11 (18%) of 61 brain tissue samples obtained from administrative autopsy cases, who apparently had not suffered from subacute sclerosing panencephalitis (SSPE)-like central nervous system disorders. Most of the brain-derived NP sequences showed significant asynonymous nucleotide substitutions when compared with wild-type MV isolates and SSPE virus. Our present results suggest that MV commonly persists in the human brain without causing apparent clinical symptoms, probably due to decreased virus replication.
    [Abstract] [Full Text] [Related] [New Search]