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  • Title: N-acetyl-L-cysteine abolishes the bromoethylamine-induced choline incorporation into renal papillary tissue.
    Author: Thielemann LE, Rodrigo RA, Oberhauser EW, Rosenblut G, Videla LA.
    Journal: J Biochem Toxicol; 1995 Oct; 10(5):251-257. PubMed ID: 8847707.
    Abstract:
    The role of regenerative processes in the protective effect of N-acetyl-L-cysteine (NAC) against bromoethylamine-induced renal papillary necrosis was assessed in rats given bromoethylamine (BEA)(1.2 mmol/kg), N-acetylcysteine (6 mmol/kg), or N-acetyl-cysteine plus BEA. Renal papillary slices were dissected after 15 hours of treatment, and 14C-choline incorporation into total phospholipid, lysophosphatidylcholine, sphingomyelin, and phosphatidylcholine was measured. Bromoethylamine elicited an increase in the incorporation of 14C-choline into choline-containing phospholipid, an effect that was abolished when N-acetylcysteine was administered prior to bromoethylamine. These studies indicate that the defensive mechanism of N-acetylcysteine against bromoethylamine-induced renal papillary necrosis is not related to regenerative processes and that N-acetylcysteine abolishes the bromoethylamine-induced choline incorporation into papillary phospholipid.
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