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  • Title: GyrB mutations in Staphylococcus aureus strains resistant to cyclothialidine, coumermycin, and novobiocin.
    Author: Stieger M, Angehrn P, Wohlgensinger B, Gmünder H.
    Journal: Antimicrob Agents Chemother; 1996 Apr; 40(4):1060-2. PubMed ID: 8849232.
    Abstract:
    The sequence of the gyrase B subunit gene from Staphylococcus aureus strains resistant to the gyrase B subunit inhibitors cyclothialidine, coumermycin, and novobiocin has been determined. The residues altered in the resistant gyrase B subunits map to the ATP-binding region, suggesting that the drugs inhibit ATP binding and hydrolysis. The pattern of cross-resistances indicates that the detailed binding mode of the compounds differs.
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