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  • Title: V-gene usage and N-region insertions in B-1a, B-1b and conventional B cells.
    Author: Kantor AB.
    Journal: Semin Immunol; 1996 Feb; 8(1):29-35. PubMed ID: 8850296.
    Abstract:
    The adult B-1a cell repertoire shows both substantial diversity and characteristic features. Recent studies using PCR to amplify variable-region transcripts from single, FACS-sorted B cells illuminate this apparent dichotomy. Although there is substantial diversity in the number of different rearrangements, characteristic patterns of VH-gene usage, combined with low use of N-region insertions when compared with conventional B cells, distinguish the B-1a repertoire. B-1b cells also have characteristic features of their own. These results are discussed in the context of key developmental and regulatory events which shape the B-1a and B-1b repertoires.
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