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  • Title: Distinctive developmental origins and specificities of the CD5+ B-cell subset.
    Author: Hardy RR, Li YS, Hayakawa K.
    Journal: Semin Immunol; 1996 Feb; 8(1):37-44. PubMed ID: 8850297.
    Abstract:
    In this review we present our recent work defining the pathway of B-cell development in the adult bone marrow of the mouse. We next present similarities and contrasts between fetal and adult B lymphopoiesis. Finally, considering the striking biases in specificity and V-gene usage between the progeny of fetal B lymphopoiesis, CD5+ B cells, and the bulk of adult-derived CD5- B cells, we suggest a model for developmentally distinct generation of this subset.
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