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  • Title: Morphological changes in the anteroventral cochlear nucleus that accompany sensorineural hearing loss in DBA/2J and C57BL/6J mice.
    Author: Willott JF, Bross LS.
    Journal: Brain Res Dev Brain Res; 1996 Feb 26; 91(2):218-26. PubMed ID: 8852372.
    Abstract:
    Morphological measurements were made on histological sections of the anteroventral cochlear nucleus (AVCN) in mice of the DBA/2J and C57BL/6J strains to determine the effects of sensorineural cochlear pathology on the number, packing density, and size of neurons and on AVCN volume. Both strains possess alleles that cause progressive cochlear pathology initially affecting the organ of Corti: in DBA mice, hearing loss is evident at 4 weeks of age and progresses rapidly; in C57 mice, hearing loss begins after 2 months of age and progresses more slowly. In both strains AVCN volume decreased, some loss of neurons occurred, and these changes paralleled the progression of peripheral hearing loss. Central changes were rapid in DBA mice, but the ultimate magnitude of the changes in 1-year-old mice did not differ between strains. Both strains differed from well-hearing CBA/J mice which exhibited no changes in the AVCN measures. The findings indicate that pathology of the organ of Corti in adult mice results in degenerative changes in the cochlear nucleus. The data also support earlier findings indicating that, if cochlear pathology does not begin prior to young adulthood, the age of onset and duration of sensorineural impairment have little effect on the ultimate magnitude of central effects.
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