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  • Title: The effect of heparin on the interaction of factor VIII and human platelets in vitro.
    Author: de Marco L, Fabris F, Molaro G, Girolami A.
    Journal: Haemostasis; 1977; 6(3):163-70. PubMed ID: 885379.
    Abstract:
    Heparin was found to inhibit the interaction between human factor VIII and platelets. This was noted in two different systems, namely, platelet aggregation induced by neuraminidase-treated human cryoprecipitate and platelet aggregation induced by ristocetin-human factor VIII complex. Heparin appeared to have an inhibitory effect on the above systems similar to that reported on bovine factor VIII-induced platelet aggregation.
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