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  • Title: Imaging of dopamine transporters in humans with technetium-99m TRODAT-1.
    Author: Kung HF, Kim HJ, Kung MP, Meegalla SK, Plössl K, Lee HK.
    Journal: Eur J Nucl Med; 1996 Nov; 23(11):1527-30. PubMed ID: 8854853.
    Abstract:
    Technetium-99m TRODAT-1, a tropane derivative, has shown promise as a tracer for the imaging of dopamine transporters in preliminary studies in rats and baboons. The present report concerns the first study of the use of [99mTc]TRODAT-1 for the same purpose in humans. The specific uptake of [99mTc]TRODAT-1 in dopamine transporter sites located in the basal ganglia area was confirmed: the best contrast between the basal ganglia and the occipital area, which is devoid of dopamine transporters, was achieved at 120-140 min following injection. The development of a 99mTc-based agent bypasses the need for cyclotron-produced radionuclides, which will be of benefit for routine clinical studies.
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