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  • Title: Luteal function in unilaterally hysterectomized ewes treated with gonadotropin-releasing hormone.
    Author: Whitmore DL, Bechert US, Rowe KE, Stormshak F.
    Journal: J Anim Sci; 1996 Aug; 74(8):1930-5. PubMed ID: 8856447.
    Abstract:
    An experiment was conducted to examine effects of GnRH administered to ewes during metestrus on subsequent luteal and uterine functional interrelationships. Treatments consisted of GnRH (0 or 100 micrograms/d) and uterine status (intact or unilaterally hysterectomized [UHYST]). On d 12 of an estrous cycle, all ewes were unilaterally ovariectomized and one-half of these ewes were subjected to contralateral UHYST. Corpora lutea in the remaining ovary were enucleated. One-half of the intact and UHYST ewes were injected i.v. with 2 mL of GnRH on d 2 and 3 after subsequent estrus, and the remaining ewes were injected similarly with 2 mL of saline. Jugular blood samples were collected at 15-min intervals after GnRH or saline injection and analyzed for serum LH. Caudal vena caval and(or) jugular blood were collected daily from d 5 to 10 and on d 12 and 14 of the cycle and analyzed for progesterone, oxytocin, and prostaglandin F2 alpha (PGF2 alpha). Injection of ewes with GnRH increased serum concentrations of LH within 60 min compared with those of saline-treated ewes (P = .01). Treatment with GnRH did not alter concentrations of oxytocin in intact or UHYST ewes (P > .10) but on d 12 and 14 mean jugular concentrations of oxytocin were greater (P = .01) in intact than in UHYST ewes. Vena cava plasma concentrations of PGF2 alpha did not differ (P > .10) among treatments. Treatment with GnRH did not affect (P > .10) serum concentrations of progesterone, but concentrations of this steroid over the sampling period tended to be greater (P = .09) in UHYST ewes than in intact ewes. In conclusion, treatment of intact and UHYST ewes with GnRH failed to alter systemic concentrations of oxytocin, PGF2 alpha, and progesterone; however, the concentrations of oxytocin were affected by unilateral hysterectomy.
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