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  • Title: Structure of a replication-terminator protein complexed with DNA.
    Author: Kamada K, Horiuchi T, Ohsumi K, Shimamoto N, Morikawa K.
    Journal: Nature; 1996 Oct 17; 383(6601):598-603. PubMed ID: 8857533.
    Abstract:
    The crystal structure of the Escherichia coli replication-terminator protein (Tus) bound to terminus-site (Ter) DNA has been determined at 2.7 A resolution. The Tus protein folds into a previously undescribed architecture divided into two domains by a central basic cleft. This cleft accommodates locally deformed B-form Ter DNA and makes extensive contacts with the major groove, mainly through two interdomain beta-strands. The unusual structural features of this complex may explain how the replication fork is halted in only one direction.
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