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  • Title: Rhabdomyolysis: a rare adverse effect of diphenhydramine overdose.
    Author: Emadian SM, Caravati EM, Herr RD.
    Journal: Am J Emerg Med; 1996 Oct; 14(6):574-6. PubMed ID: 8857809.
    Abstract:
    Drug- and toxin-induced rhabdomyolysis is a nonspecific clinical syndrome resulting from the release of skeletal muscle cell contents into the plasma and urine. Antihistamine drugs are the active ingredients in a number of over-the-counter preparations and are frequently ingested in suicide attempts. We report rhabdomyolysis as a rare adverse effect of diphenhydramine toxicity in a 29-year-old man who ingested an unknown quantity of an over-the-counter sleep preparation in a suicide attempt. The patient had documented toxic concentration of diphenhydramine in his cerebrospinal fluid and no history of seizures, coma, or hypothermia. A high index of suspicion and an evaluation for rhabdomyolysis is warranted in antihistamine toxicity.
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