These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Inflammatory cytokines, nitric oxide, and necrotizing enterocolitis.
    Author: Ford HR, Sorrells DL, Knisely AS.
    Journal: Semin Pediatr Surg; 1996 Aug; 5(3):155-9. PubMed ID: 8858761.
    Abstract:
    Numerous theories have been proposed to explain the pathogenesis of necrotizing enterocolitis (NEC). Current evidence suggests that injury to the intestinal barrier as a result of various perinatal insults may facilitate invasion of the intestinal wall by bacteria. An inflammatory cascade ensues, characterized by local release of various cytokines that may contribute to further tissue destruction and hemodynamic instability in NEC. Molecular biological probes show increased expression of inducible nitric oxide synthase and interferon-gamma in the intestine of infants with NEC. Studies are planned to define the role of these inflammatory mediators in a rat model of NEC.
    [Abstract] [Full Text] [Related] [New Search]