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  • Title: The influence of beta-adrenoceptor blocking agents on plasma thyroxine and triiodothyronine.
    Author: Wiersinga WM, Touber JL.
    Journal: J Clin Endocrinol Metab; 1977 Aug; 45(2):293-8. PubMed ID: 885993.
    Abstract:
    The effect of the beta-adrenoceptor blocking agent propranolol on plasma levels of thyroxine and triiodothyronine was studied in eleven hyperthyroid patients and in six hypothyroid patients on L-thyroxine substitution therapy. In all patients a decrease in plasma-triiodothyronine was found. The per cent decrease of plasma-triiodothyronine was the same in both groups. Plasma levels of thyroxine and thyrotropin increased in the hypothyroid patients, but remained constant in the hyperthyroid subjects. The decrease in plasma-triiodothyronine during propranolol medication is most likely caused by an inhibition of the peripheral conversion of thyroxine into triiodothyronine.
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