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  • Title: Cloning and sequencing of an equine insulin-like growth factor I cDNA and its expression in fetal and adult tissues.
    Author: Otte K, Rozell B, Gessbo A, Engström W.
    Journal: Gen Comp Endocrinol; 1996 Apr; 102(1):11-5. PubMed ID: 8860303.
    Abstract:
    A cDNA for equine insulin-like growth factor I (IGF I) has been isolated by reverse transcriptase-polymerase chain reaction and subsequently sequenced. The sequenced fragment contained 465 bp including the coding regions for the signal peptide, the entire mature protein, and 4 amino acids into the E-peptide. Like its human counterpart, the mature equine IGF I peptide contains 70 amino acids and was 100% homologous between horse and man. The 49-amino-acid signal peptide had the threonine in position 26 of the human signal peptide substituted by isoleucine. The nucleotide homology across the entire clone was 96.3% between horse and man and 91.6% between horse and rat. The isolated cDNA hybridized to the same transcripts in fetal and adult tissues.
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