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  • Title: Primary dapsone resistance in Cebu, The Philippines; cause for concern.
    Author: dela Cruz E, Cellona RV, Balagon MV, Villahermosa LG, Fajardo TT, Abalos RM, Tan EV, Walsh GP.
    Journal: Int J Lepr Other Mycobact Dis; 1996 Sep; 64(3):253-6. PubMed ID: 8862258.
    Abstract:
    At a time when primary dapsone resistance was prevalent in many leprosy endemic areas, Cebu in The Philippines reported only 3.6% in the period 1975-1978 and later 8.1% in the period 1979-1982. In our current study of patients in the period 1988-1992, the number increased dramatically to 52.7%. In addition, 7.9% of the isolates are highly resistant to dapsone, a level of resistance not seen in earlier studies. This finding could have severe ramifications to the World Health Organization's multidrug therapy (WHO-MDT) mode of treatment, where dapsone is one of the principal drugs. Moreover, the increase in primary dapsone resistance may be a contributing factor in the recent finding that there has been no decline in the number of new cases found in Cebu, even after the implementation of WHO-MDT in 1985. There is a need for new drugs that could be included in the multidrug treatment for multibacillary and paucibacillary leprosy.
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