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  • Title: Techniques for investigation of an apparent outbreak of infections with Candida glabrata.
    Author: Arif S, Barkham T, Power EG, Howell SA.
    Journal: J Clin Microbiol; 1996 Sep; 34(9):2205-9. PubMed ID: 8862586.
    Abstract:
    A cluster of Candida glabrata isolates recovered from seven patients in an intensive care unit over a 10-week period were compared with a collection of isolates from six epidemiologically distinct outpatients and a reference strain by several DNA typing methods. Restriction enzyme analysis with HinII distinguished 13 strains from the 14 sources and was the method of choice. Pulsed-field gel electrophoresis and random amplification of polymorphic DNA both detected nine types from the 14 sources; however, the results of these two methods did not always correlate. These methods demonstrated that five of the seven patients had distinguishable strains and that cross-infection was unlikely.
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