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  • Title: Cocaine inhibits the release of MPP+ but not dopamine through the rat dopamine transporter.
    Author: Kitayama S, Morita K, Dohi T.
    Journal: Eur J Pharmacol; 1996 Aug 01; 309(1):107-9. PubMed ID: 8864700.
    Abstract:
    Transporter-mediated release of dopamine and the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium (MPP+) was examined in COS cells, a cell line derived from monkey kidney, expressing the rat dopamine transporter. The release of preloaded [3H]MPP+ but not [3H]dopamine was dose-dependently inhibited by cocaine and other compounds known as dopamine uptake inhibitor, 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-piperazine (GBR12,935) and nomifensine, although the uptake of both [3H]dopamine and [3H]MPP+ was sensitive to these compounds. The different sensitivity of the outward transport of dopamine and MPP+ to the uptake inhibitors might provide a clue to the identity of the specific site(s) for cocaine on the transporter.
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