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  • Title: Cytomegalovirus causing necrotizing laryngitis in a renal and cardiac transplant recipient.
    Author: López-Amado M, Yebra-Pimentel MT, García-Sarandeses A.
    Journal: Head Neck; 1996; 18(5):455-7; discussion 457-8. PubMed ID: 8864737.
    Abstract:
    BACKGROUND: Cytomegalovirus (CMV) infection is a common opportunistic pathogen in transplant recipients; however, cytomegaloviral laryngitis is extremely rare. METHODS: We present a case of disseminated CMV infection and ulcerating necrotizing laryngitis situated in the subglottis of an immunocompromised patient with a renal and cardiac transplant. The patient was initially seen with discomfort in the throat. RESULTS: Physical examination of the head and neck, fiberoptic laryngoscopy, and CT scan of the larynx were normal. Histopathology of a laryngeal ulcer in the subglottic region showed intranuclear and intracytoplasmic bodies. Immunoperoxidase stain and in situ hybridization studies were positive for CMV. CONCLUSIONS: In immunosuppressed patients with persistent throat symptoms, the systematic exploration of larynx and bronchus is necessary to rule out the presence of opportunistic infections.
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