These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Respiratory muscle coordination in acute spinal dogs.
    Author: Reinoso MA, Sieck GC, Hubmayr RD.
    Journal: Respir Physiol; 1996; 104(1):29-37. PubMed ID: 8865379.
    Abstract:
    Our objectives were (1) to test whether respiratory muscles of spinal dogs can generate the alternating pattern of activation seen in intact animals and (2) to characterize the responsiveness of spinal rhythms to mechanical ventilation. We recorded the electromyographic activities of inspiratory muscles (diaphragm and parasternal intercostals) and expiratory muscles (triangularis sterni and transversus abdominis) in ten anesthetized dogs before and after transection of the cervical cord at levels C1-C2 (n = 2), C2-C3 (n = 6), and C8 (n = 2). In 9/10 dogs, we observed short lasting (3-4 min) rhythmic ventilatory muscle activity for up to 3 h after transection. Inspiratory and expiratory muscles contracted simultaneously, suggesting an absence of mechanism(s) responsible for reciprocal muscle activation on a spinal level. Five of ten dogs showed tonic rib cage activity during apnea that was phasically modulated during mechanical ventilation. From the absence of alternating inspiratory and expiratory muscle activity in acute spinalized dogs, we conclude that dogs do not have a spinal pattern generator for respiration.
    [Abstract] [Full Text] [Related] [New Search]