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  • Title: Losses at 3p common deletion sites in subtypes of kidney tumours: histopathological correlations.
    Author: Hadaczek P, Podolski J, Toloczko A, Kurzawski G, Sikorski A, Rabbitts P, Huebner K, Lubinski J.
    Journal: Virchows Arch; 1996 Sep; 429(1):37-42. PubMed ID: 8865851.
    Abstract:
    Deletions of the short arm of chromosome 3 (3p) have been recognized as characteristic features of clear cell renal cell carcinomas (clear cell RCC). We analysed 55 clear-cell RCCs and 30 non-clear-cell kidney tumours (10 papillary and 7 chromophobic RCCs, 11 oncocytomas and 2 collecting duct carcinomas) in loss of heterozygosity (LOH) studies using microsatellite markers for previously observed regions of common deletions on 3p in kidney tumours (3p25, 3p21.3, 3p14.2 and 3p12-13). Alterations were found in all 55 cases of clear-cell RCCs at two to four of the 3p regions. Extensive losses were not found in non-clear-cell tumours except for collecting duct carcinomas; 1 of 10 papillary RCCs showed interstitial deletion limited to a single 3p21.3 locus. LOH analyses using microsatellite markers for regions of common deletions at 3p may be of value in differential diagnosis of kidney tumours.
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