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  • Title: Control serum for therapeutic drug monitoring.
    Author: Schneiderka P, Hostlovská M, Loub L.
    Journal: Sb Lek; 1994; 95(4):373-81. PubMed ID: 8867709.
    Abstract:
    New control material EXAPHARM (IMUNA s.p., Sarisské Michalany, Slovakia) for therapeutic drug monitoring (TDM) was evaluated. It is produced in two types: Exapharm AED containing 6 antiepileptic drugs and Exapharm CARD with 4 cardiac and antiasthmatic drugs. Both contain horse serum as a matrix, which is different in some parameters from human serum. Our results approved an outstanding stability and inter-bottle homogeneity of the material. Evidence was presented that no interferences occur in high performance liquid chromatography (HPLC) under the conditions described. It is concluded, that this control serum is very suitable for TDM by HPLC.
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