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  • Title: Synthesis and pharmacological properties of 2,4-disubstituted 5-amino-6-pyrimidinecarboxylic acid derivatives. Part III.
    Author: Jasztold-Howorko R, Machoń Z, Wilimowski M, Wojewódzki W, Barczyńska J, Kedzierska L, Orzechowska-Juzwenko K, Duś E, Dziewiszek W, Rutkowska M.
    Journal: Pol J Pharmacol; 1995; 47(5):435-40. PubMed ID: 8868136.
    Abstract:
    2,4-Disubstituted 5-amino-6-pyrimidinecarboxylic acid derivatives 5-13 were synthesized and evaluated for their pharmacological activity. Compounds 5, 7, 9, 10 and 12 showed antiaggressive effect, compounds 6 and 10 showed synergism with hexobarbital while compound 6 exerted analgesic activity.
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