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  • Title: Histamine-and isoprenaline-evoked stimulation of cAMP formation in chick cerebral cortex.
    Author: Nowak JZ, Zawilska JB.
    Journal: Pol J Pharmacol; 1995; 47(6):541-4. PubMed ID: 8868378.
    Abstract:
    Histamine (HA) and isoprenaline (ISO) strongly stimulated cAMP formation in chick cerebral cortical slices. The effects of HA and ISO were selectively antagonized by HA H2-receptor blockers (aminopotentidine, ranitidine) and beta-adrenoceptor blocker propranolol, respectively. The combination of HA (0.1-100 microM) and ISO (0.1-10 microM) produced some additive effects when the drugs were used at low concentrations, i.e. 0.1-1 microM but not when HA was applied at 10 or 100 microM doses (which evoked nearly maximal effect). It is suggested that HA H2-like receptors and beta-adrenoceptors (whose activation leads to stimulation of cAMP formation) are localized in the same subpopulation of cortical cells, in which they probably utilize a common and limited pool of cAMP-generating system.
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