These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Two cases of fatal zopiclone overdose.
    Author: Boniface PJ, Russell SG.
    Journal: J Anal Toxicol; 1996; 20(2):131-3. PubMed ID: 8868406.
    Abstract:
    Two cases of death due to the ingestion of zopiclone are presented. Quantitative determinations of zopiclone yielded 1.4-3.9 mg/L in the blood, 0.81 and 8.7 mg/kg in the liver, and 13.5 and 133 mg in the stomach contents. Drug concentrations were interpreted relative to the case findings, published data, and a limited evaluation of therapeutic concentrations found in two cases of therapeutic zopiclone use. Zopiclone was extracted from buffered blood or digested liver or both with n-butyl chloride and analyzed by high-performance liquid chromatography with ultraviolet detection. Liver samples were digested at pH 7 to avoid zopiclone decomposition.
    [Abstract] [Full Text] [Related] [New Search]