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  • Title: Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles.
    Author: Prevedello MR, Ritta MN, Cardinali DP.
    Journal: Neurosci Lett; 1979 Jun; 13(1):29-34. PubMed ID: 88700.
    Abstract:
    The effect of pineal indoles on fast axoplasmic transport of proteins in the sciatic nerve was examined in rats injected with [3H]leucine in the sixth lumbar dorsal root ganglion. Melatonin (350-1100 nmol) applied locally in the sciatic nerve impaired significantly axonal transport. At a 350-nmol dose all other indoles tested (i.e., 5-hydroxyindoleacetic acid, 5-methoxyindoleacetic acid, serotonin, N-acetylserotonin, tryptamine, 5-methoxytryptamine) were less potent than melatonin to impair fast axonal flow. Vinblastine injected either into the ganglion or in the sciatic nerve markedly inhibited axonal transport.
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