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  • Title: Human parvovirus B19 infection within a family and risk for pregnant women.
    Author: Azzi A, Trotta M, Zakrzewska K, Balzer E, Rogasi PG, Carocci A, Leoncini F.
    Journal: Epidemiol Infect; 1996 Oct; 117(2):401-3. PubMed ID: 8870639.
    Abstract:
    During an outbreak of parvovirus B19 infection among four related families at least 70% of the household contacts, including a woman at the 33rd week of pregnancy, became infected. Twins were born at the 39th week of pregnancy, both with B19 infection. B19 DNA was detected in their sera by a nested PCR, anti-B19 IgM was detectable only by an immunofluorescence assay, and low levels of maternal anti-B19 IgG were demonstrable by an immunoenzymatic test in the serum of both children. All the haematological parameters were normal at birth and 6 months later, when B19 DNA and anti-B19 antibody were no longer detectable in serum samples. This observation emphasizes the high risk of B19 infection among household contacts and the possibility of a favourable outcome of the foetal infection, possibly related to infection late in the pregnancy.
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