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  • Title: Mechanisms regulating eosinophil extravasation in asthma.
    Author: Knol EF, Roos D.
    Journal: Eur Respir J Suppl; 1996 Aug; 22():136s-140s. PubMed ID: 8871059.
    Abstract:
    Infiltration of eosinophils into tissue allergic inflammation is mediated by a combination of processes. Eosinophil L-selection and very late activation antigen (VLA-4) can selectively regulate eosinophil adhesion to the endothelium. Activating cytokines, such as interleukin (IL)-5, regulated upon activation in normal T-cells (RANTES) and monocyte chemotactic peptide (MCP)-3 specifically act on eosinophils. Moreover, eosinophils from allergic individuals can be primed for increased adhesion and movement by chemokines released at sites of allergic inflammation. Together, these processes induce a specific infiltration of eosinophils.
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