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  • Title: Lectin-histochemical study of O-linked glycoconjugates in dysplastic retina of Norrie disease.
    Author: Uehara F, Sameshima M, Yanagita T, Iwakiri N, Ohba N.
    Journal: Jpn J Ophthalmol; 1996; 40(2):251-4. PubMed ID: 8876395.
    Abstract:
    The carbohydrate chains of O-linked glycoconjugates in dysplastic retina from a Japanese female infant with Norrie disease were examined by lectin histochemistry. The avidin-biotinylated peroxidase method was used. The retina was highly dysplastic and composed of undifferentiated embryonic tissues containing a number of rosettes of varying sizes. The lumina of the rosettes were stained by peanut agglutinin, which recognizes the Gal beta 1,3GalNAc sequence of O-linked glycans. However, the lumina were not labeled by wheat germ agglutinin, which reacts with sialic acid and/or N-acetylglucosamine. These observations suggest that the O-linked glycoconjugates in the lumina of rosettes were not sialylated in the present case. Their lack of terminal sialic acids may be related to the rosette formation.
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