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  • Title: Toxicity and enzyme-inducing effect of the antiviral compound mopyridone in mice.
    Author: Tantcheva LP, Rangelova DS.
    Journal: Arzneimittelforschung; 1996 Sep; 46(9):931-3. PubMed ID: 8876945.
    Abstract:
    Mopyridone (CAS 82822-14-8, MP) is a new antiviral compound with low acute toxicity in mice. Phenobarbital (PB) induction did not alter MP oral acute toxicity, while methylcholanthrene (MC) and dexamethasone (DEX) induction increased it. MP (1/10 of LD50, 5 days) increased aniline hydroxylase activity (by 158%) and cytochrome P-450 content (by 43%), but has no significant effect on liver N-demethylase activity (ethylmorphine N-demethylase, amidopyrine N-demethylase and benzphetamine N-demethylase) in mouse liver 10,000 x g supernatant. The inducing effect of MP was similar to the effect of MC and differed from the effect of PB. The combination MP + PB exerted an additive inducing effect on aniline hydroxylase (by 390%) and cytochrome P-450 content (by 183%) without affecting PB induced N-demethylases. The character of the MP + PB interaction was similar to that of the MC + PB interaction and suggested different inducing mechanisms of MP and PB. The participation of some cytochrome P-450 isozymes, induced by MC and DEX, in biotransformation of MP to more toxic product(s) was suggested.
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