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  • Title: Inhibitory effects of cocaine on NGF-induced neuronal differentiation: incomplete reversibility after a critical time period.
    Author: Zachor DA, Moore JF, Smoot TM, Percy AK.
    Journal: Brain Res; 1996 Aug 12; 729(2):270-2. PubMed ID: 8876998.
    Abstract:
    We extend our findings showing dose-dependent cocaine inhibition of differentiation in NGF-stimulated PC-12 cells without affecting cell viability by demonstrating that neurite extension is severely limited after 24 h, maximal effect is reached at 36 h and recovery is only partial. Cocaine metabolites lack these effects. A similar process may occur following human prenatal exposure, perhaps through cocaine-induced changes in gene expression or other intracellular signalling events.
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