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  • Title: Effect of epinine on tension of human renal arteries.
    Author: Schwinger RH, Schulz C, Brixius K, Böhm M, Müller-Ehmsen J, Erdmann E.
    Journal: Naunyn Schmiedebergs Arch Pharmacol; 1996; 354(3):343-7. PubMed ID: 8878065.
    Abstract:
    BACKGROUND: The present study aimed to characterize the effects of epinine, the active metabolite of ibopamine on tension development in human renal arteries. METHODS AND RESULTS: Experiments were performed on isolated human renal arteries rings obtained during surgery due to kidney tumors (n = 12). Epinine concentration-dependently relaxed isolated precontracted (PGF2 alpha) human renal artery rings (P < 0.05) in the presence of phentolamine, as effectively (epinine -30 +/- 4 mN, dopamine -31 +/- 5 mN) and with the same potency as dopamine (epinine EC50 0.7 mumol/l (0.4-1.2 mumol/l), dopamine 0.5 mumol/l (0.2-1.7 mumol/l). This effect was antagonized by the specific D1-receptor-antagonist SCH 23390. Effective beta-adrenoceptor antagonistic concentrations of propranolol did not affect epinine-induced vasorelaxation. In the absence of alpha- and beta-adrenoceptor-antagonists the potency of epinine to contract renal artery rings was significantly higher compared to dopamine indicating a higher affinity of epinine to alpha-adrenoceptors. CONCLUSION: The present study provides evidence for direct vasodilatory effects of epinine via activation of D1-receptors on human renal arteries.
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