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  • Title: Calcium-dependent potentiation of M-current in bullfrog sympathetic neurons.
    Author: Tokimasa T, Shirasaki T, Yoshida M, Ito M, Tanaka E, Mitsumoto T, Akasu T, Tanaka M, Higashi H, Nakano T.
    Journal: Neurosci Lett; 1996 Aug 23; 214(2-3):79-82. PubMed ID: 8878088.
    Abstract:
    Whole-cell voltage-clamp recordings were made from cultured bullfrog sympathetic neurons to measure the steady-state activation curve of M-type potassium current. When measured with a calcium-deficient (10 nM) pipette solution M-conductance was 4.8 nS at -35 mV having the 50%-activation voltage at-20 mV. Respective values were 17.2 nS at -35 mV with the 50%-activation voltage at -42 mV when measured with a calcium-rich (1 microM) solution, indicating the hyperpolarizing displacement of the activation curve with high internal calcium. It is suggested that intracellular calcium ions can modulate kinetics of M-current which thereby regulate the number of M-channels being open at given membrane potentials.
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