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  • Title: Effects of a nitric oxide synthase inhibitor on prostaglandin-induced aqueous flare elevation in pigmented rabbits.
    Author: Hiraki S, Zhang XY, Hayasaka S.
    Journal: Ophthalmic Res; 1996; 28(4):260-4. PubMed ID: 8878190.
    Abstract:
    To evaluate the possible role of nitric oxide in the pathogenesis of exogenous prostaglandin (PG) induced aqueous flare elevation, we examined the effect of NG-nitro-L-arginine methyl ester (L-NAME), an L-arginine analogue acting as a specific inhibitor of nitric oxide synthase, on the elevation of aqueous flare in pigmented rabbits. L-NAME was injected into the ear vein of the animals. PGE1, PGE2, and PGF2 alpha were administered topically to the cornea using a glass cylinder. Aqueous flare was measured using a laser flare cell meter. PGE1, PGE2, and PGF2 alpha increased the aqueous flare dose dependently (5-100 micrograms/ml). L-NAME inhibited PGE1-, PGE2-, or PGF2 alpha-induced aqueous flare elevation. L-NAME, injected 30-90 min before PG application, inhibited the aqueous flare elevation maximally. We believe that nitric oxide may be involved in the pathogenesis of PG-induced aqueous flare elevation in rabbits.
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