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  • Title: The usefulness of dapiprazole, an alpha-adrenergic blocking agent, in pigmentary glaucoma.
    Author: Mastropasqua L, Carpineto P, Ciancaglini M, Gallenga PE.
    Journal: Ophthalmic Surg Lasers; 1996 Sep; 27(9):806-9. PubMed ID: 8878205.
    Abstract:
    The aim of this study was to increase understanding of the usefulness of an alpha-adrenergic blocking agent, dapiprazole 0.5% eyedrops, as an adjunct in antiglaucomatous therapy for 20 patients with pigmentary glaucoma receiving timolol 0.5% and pilocarpine 1%. After 12 months of dapiprazole treatment, the difference from the pretreatment mean intraocular pressure (IOP) value was statistically significant (P = .005). After 12 and 36 months of treatment, an hour-to-hour comparison of diurnal IOP curve values showed a statistically significant difference in all cases (P < .001). Although further investigations may be necessary to reach a definite conclusion, dapiprazole appeared to have a beneficial, stable in time effect in these patients.
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