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  • Title: In vitro activity of BMS-181184 compared with those of fluconazole and amphotericin B against various candida spp.
    Author: Wardle HM, Law D, Denning DW.
    Journal: Antimicrob Agents Chemother; 1996 Sep; 40(9):2229-31. PubMed ID: 8878616.
    Abstract:
    We compared the in vitro activity of BMS-181184, the first compound of a new class of antifungal agents, the pradimicins, with those of fluconazole and amphotericin B against 64 clinical isolates of Candida species. MICs were determined by a microdilution method with high resolution medium for BMS-181184 and fluconazole and antibiotic medium no. 3 with 2% glucose for amphotericin B. MICs of BMS-181184 for all yeasts were in the range of 0.78 to 12.5 micrograms/ml. BMS-181184 was active against isolates resistant to other antifungal agents, consistent with a novel mode of action. Minimum fungicidal concentrations for 16 isolates showed that BMS-181184 was fungicidal. Clinical studies are now required to confirm its activity.
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