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  • Title: Quantitation of dimethylnitrosamine in the whole mouse after biosynthesis in vivo from trace levels of precursors.
    Author: Rounbehler DP, Ross R, Fine DH, Iqbal ZM, Epstein SS.
    Journal: Science; 1977 Aug 26; 197(4306):917-8. PubMed ID: 887934.
    Abstract:
    A simple and highly sensitive procedure is described for the recovery and quantitative identification of nanogram quantities of preformed N-nitroso compounds in the whole mouse. This procedure has also been applied to the quantitation of N-nitroso compounds after they have been biosynthesized from trace amounts of precursors. The whole animal is frozen in liquid nitrogen and homogenized to a frozen powder; the powder is then extracted and analyzed by a thermal energy analyzer interfaced to a gas-liquid and a high-pressure liquid chromatograph.
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