These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Vasoactive properties of prostaglandin compounds on the in vitro human basilar artery.
    Author: Yashon D, Brown RJ, Hunt WE.
    Journal: Surg Neurol; 1977 Aug; 8(2):111-5. PubMed ID: 888085.
    Abstract:
    The action of six prostaglandins A1, E1, (A2, E2, F1 alpha, F2 alpha) on in vitro human basilar artery circumferential strips was evaluated to assess relative vasoreactivity. Degree of contraction was compared with 5-hydroxytryptamine (5-HT), hitherto the most active in this laboratory. The three most vasoactive prostaglandins were E1, E2, and F2, alpha. The three PGs giving highest magnitude of response were F1 alpha, F2 alpha, and E2. Most were more active when compared to 5-HT. Vasodilation did not occur. Because of their vasoconstrictive qualities, prostaglandins may participate in arterial vasospasm. It is postulated that prolonged vasoconstriction may lead to vasospasm and that the latter may result from one or more autacoids acting along or synergistically.
    [Abstract] [Full Text] [Related] [New Search]