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  • Title: [Peripheral neuropathies associated with IgM monoclonal gammopathy: clinical and electrophysiological aspects].
    Author: Léger JM, Chassande B, Bouche P.
    Journal: Rev Neurol (Paris); 1996 May; 152(5):394-9. PubMed ID: 8881438.
    Abstract:
    Polyneuropathies associated with IgM monoclonal gammopathy (IgM-MG) are the most frequent type of peripheral neuropathy (PN) associated with monoclonal gammopathy. The pathogenic relevance of IgM-MG in PN is supported by several arguments, the more significants are pathological data on neuromuscular biopsies and the demonstration of IgM antibody activity to peripheral nerve antigens, mainly myelin-associated-glycoprotein (MAG) and sulfated glucuronyl paragloboside (SGPG). In addition recently reported series show that there is a significant correlation between clinical/electrophysiological data of PN, and IgM-MG antibody activity, in more than 75% of cases. Those features are in favour of an immune-mediated disease.
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