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  • Title: Inhibition of D-amino acid oxidase by alpha-keto acids analogs of amino acids.
    Author: Moreno JA, Montes FJ, Catalán J, Galán MA.
    Journal: Enzyme Microb Technol; 1996 Apr; 18(5):379-82. PubMed ID: 8882005.
    Abstract:
    The inhibition of D-amino acid oxidase by certain alpha-keto acids products of the reaction with D-amino acids, in particular alpha-keto acids that are analogs of the amino acids alanine, valine, leucine, phenylanaline, phenylglycine, tyrosine and tryptophan, is reported. All the alpha-keto acids assayed behaved as substrate competitive inhibitors of the enzyme. The relationship between the degree of inhibition and the structure of the inhibitor is discussed.
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