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  • Title: Serum proteins in prostatic cancer. V. Alterations in immunoglobulins and clinical responsiveness following cryoprostatectomy.
    Author: Ablin RJ, Soanes WA, Gonder MJ.
    Journal: Urol Int; 1977; 32(1):56-64. PubMed ID: 888251.
    Abstract:
    Levels of the three major serum immunoglobulins (G, A, M) were quantitated prior to and up to 2 weeks following each of two independent freezing treatments of the primary prostatic tumour in 4 patients undergoing remission or healing of their metastatic lesions. Cyclical alterations in the level of IgG accompanied by moderate alterations in the level of IgA were noted post-operatively. Most striking was an almost twofold increase in the level of IgM in 3 of the 4 patients evaluated. While possibly a non-specific association, observations of increased levels of IgG and IgM following cryotherapy may represent an active immunologic response by the host to prostatic tissue (tumour?)-specific or tumour-associated antigen(s) in the form of 'blocking' factor(s) or cytotoxic antibody.
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