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  • Title: Pathogenicity, attenuation, and immunogenicity of infectious bursal disease virus.
    Author: Hassan MK, Al-Natour MQ, Ward LA, Saif YM.
    Journal: Avian Dis; 1996; 40(3):567-71. PubMed ID: 8883785.
    Abstract:
    An investigation was conducted in specific-pathogen-free chickens on the pathogenicity of bursa-derived and tissue culture-attenuated classic (STC) and variant (IN) serotype 1 strains of infectious bursal disease virus. The IN bursa-derived virus caused bursal inflammation, necrosis, and atrophy earlier than the bursa-derived STC virus. Both viruses lost their pathogenicity after four passages in BGM-70 cells. A statistically significant level (P < 0.05) of protection was observed in SPF chickens vaccinated with the attenuated IN virus used as a live or inactivated vaccine followed by homologous (IN) and heterologous (STC) challenge with bursa-derived viruses.
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